All in Article summary

Translation is Tricky

I read a paper that is well written and a surprising development in the field of gene/DNA therapeutics, so I wanted to share and summarize it, with a special focus on molecular biology. The title says it all, but you gotta be careful not to jump to conclusions: it’s not the AAV that seems to be the problem, nor is it the miRNA targeting the disease-causing gene. It turns out that the way the construct is designed causes toxic responses in animals. Cover art is a collage of the new constructs tested by Megan S. Keiser et al.

Drug stuff: Food edition

I came across some cool developments at the intersection of diet, drugs, and the brain recently, and wanted share them, including Amarin's drug patent woes, oral semaglutide results, and Adermark et al's paper on how weight gain and neuroadaptations elicited by high fat diet depend on fatty acid composition. Cover art is a meme inspired by the Vascepa saga.